Sinapic Acid Protects SH-SY5Y Human Neuroblastoma Cells against 6-Hydroxydopamine-Induced Neurotoxicity

Parkinson’s disease (PD) is characterized by progressive dopaminergic neuron loss or dysfunction and the second most prevalent neurodegenerative disorder after Alzheimer’s disease. However, current therapeutic strategies for PD are limited to treating outcomes of this rather than preventing it. Sinapic acid (SA) a phenolic compound with potential antioxidant properties, which reportedly acts as agent against many diseases including cancer, well cardiac liver diseases. little known about effects SA disorders. Therefore, our study sought evaluate neuroprotective non-cytotoxic concentrations 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in SH-SY5Y human neuroblastoma cells, we used an vitro model. increased cell viability rescued cells from 6-OHDA-induced apoptotic death. Additionally, oxidative stress responses were significantly blocked SA, reactive oxygen species (ROS) overproduction decreased expression levels proteins. Notably, also attenuated mitochondrial endoplasmic reticulum (ER) stress. Moreover, dramatically inhibited activation mitogen-activated protein kinase (MAPK) Taken together, findings highlight prevention its underlying mechanisms, making promising treatment PD.